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Dna A Protein

Dna A is responsible for starting the formation on the replication bubble.  The Dna A protein binds to the 9 base pairs repeats.  This is a repeated nine base pair sequence on the right side of the oriC sequence.  Four Dna A proteins  bind to this repeated sequence starting the formation of the replication bubble.  Then Dna A proteins bind cooperatively together to form a Dna A complex that is wrapped on the surface with the oriC sequence.  This cause strand separation in the 13-mers which binds the Dna B proteins.

References:

1. Cox, M. and Nelson, D. (2000) Lehninger Principles of Biochemistry. Pg 941-946.

2. Snustad and Simmons. (2000) Principles of Genetics. Pg 255-280

3. Weaver, R. F. (1999) Molecular Biology. Pp. 668- 669.